Identifying protease cleavage sites by label‐free mass spectrometry
نویسندگان
چکیده
منابع مشابه
FAK phosphorylation sites mapped by mass spectrometry.
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متن کاملHuntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.
Huntingtin (Htt) is a large protein of 3144 amino acids, whose function and regulation have not been well defined. Polyglutamine (polyQ) expansion in the N terminus of Htt causes the neurodegenerative disorder Huntington disease (HD). The cytotoxicity of mutant Htt is modulated by proteolytic cleavage with caspases and calpains generating N-terminal polyQ-containing fragments. We hypothesized t...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.905.4